Protein name:
Prostatic acid phosphatase ;
Alternative:
Ecto-5'-nucleotidase ;3.1.3.5;5'-nucleotidase (5'-NT) ;Thiamine monophosphatase (TMPase) ;Fluoride-resistant acid phosphatase (FRAP) ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Homodimer; dimer formation is required for phosphatase activity.
Function:
Isoform 2: the cellular form also has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor.
Subcellular Location:
Isoform 2
Cell membrane
Single-pass type I membrane protein
Lysosome membrane
Single-pass type I membrane protein
Appears to shuttle between the cell membrane and intracellular vesicles. Colocalizes with FLOT1 at cell membrane and in intracellular vesicles. Colocalizes with LAMP2 on the lysosome membrane.
Protein Attributes:
50:
MRAVPLHLVG | TASLTLGFLL | LLSLRLDPGQ | AKELKFVTLV | FRHGDRGPIE |
100:
TFPNDPIKES | SWPQGFGQLT | KWGMGQHYEL | GSYIRRRYGR | FLNNSYKHDQ |
150:
VYIRSTDVDR | TLMSAMTNLA | ALFPPEGISI | WNPRLLWQPI | PVHTVSLSED |
200:
RLLYLPFRDC | PRFQELKSET | LKSEEFLKRL | QPYKSFIDTL | PSLSGFEDQD |
250:
LFEIWSRLYD | PLYCESVHNF | TFRTWATEDA | MTKLKELSEL | SLLSLYGIHK |
300:
QKEKSRLQGG | VLVNEILKNM | KLATQPQKAR | KLIMYSAYDT | TVSGLQMALE |
350:
LYNGLLPPYA | SCHIMELYQD | NGGTFVEMYY | RNETQNEPYP | LTLPGCTHSC |
381:
PLEKFAELLD | PVIPQDWATE | CMGTSNHQAS | L
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
Bovine
ELISA Kit for Rat Prostatic acid phosphatase
ELISA Kit for Rat Prostatic acid phosphatase
ELISA Kit for Rat Prostatic acid phosphatase
ELISA Kit for Rat Prostatic acid phosphatase
CLIA Kit for Rat Prostatic acid phosphatase
CLIA Kit for Rat Prostatic acid phosphatase
CLIA Kit for Rat Prostatic acid phosphatase
CLIA Kit for Rat Prostatic acid phosphatase
Polyclonal Antibody for Rat Prostatic acid phosphatase
Polyclonal Antibody for Rat Prostatic acid phosphatase
Polyclonal Antibody for Rat Prostatic acid phosphatase
Polyclonal Antibody for Rat Prostatic acid phosphatase
Monoclonal Antibody for Rat Prostatic acid phosphatase
Monoclonal Antibody for Rat Prostatic acid phosphatase
Monoclonal Antibody for Rat Prostatic acid phosphatase
Monoclonal Antibody for Rat Prostatic acid phosphatase
Protein for Rat Prostatic acid phosphatase
Protein for Rat Prostatic acid phosphatase
Protein for Rat Prostatic acid phosphatase
Protein for Rat Prostatic acid phosphatase
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Prostate .
2.
"Prostatic acid phosphatase is not a prostate specific target."
Quintero I.B.
,
Araujo C.L.
,
Pulkka A.E.
,
Wirkkala R.S.
,
Herrala A.M.
,
Eskelinen E.-L.
,
Jokitalo E.
,
Hellstroem P.A.
,
Tuominen H.J.
,
Hirvikoski P.P.
,
Vihko P.T.
Cancer Res.67:6549-6554(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
strain :
Sprague-Dawley .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACTIVE SITE;SUBUNIT;ENZYME REGULATION;SUBSTRATE SPECIFICITY;MUTAGENESIS OF TRP-137; HIS-143; TYR-154; ARG-158 AND ASP-289
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS);SUBUNIT;GLYCOSYLATION AT ASN-93 AND ASN-332
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) IN COMPLEX WITH L(+)-TARTRATE;GLYCOSYLATION AT ASN-93 AND ASN-332